Haystack Oncology will be attending the 2023 European Society for Medical Oncology Congress (ESMO 2023) taking place in Madrid, Spain from October 20—24. ...
Haystack MRD Test
Improve patient outcomes with better MRD testing
For Clinicians
Haystack MRD™ is the most sensitive minimal residual disease (MRD) test available, so you can have the best information to make treatment management decisions that lead to favorable patient outcomes. Our unmatched test performance delivers the best clinical information when answering patients' three most pressing post-surgery questions:
01
Did my treatment work?
02
Do I need additional therapy?
03
Is the cancer recurring?



by the numbers
Why test for ctDNA?
Circulating tumor DNA (ctDNA) detection is a non-invasive method to assess tumor burden with a blood sample. Recent data also correlate ctDNA levels in post-surgical cancer patients with recurrence-free survival (RFS) and risk of recurrence.
3-yr RFS*
3-yr RFS*
more likely to recur
*Tie J, Wang Y, Tomasetti C, et al. Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer. Sci Transl Med. 2016;8(346):346ra92. doi:10.1126/scitranslmed.aaf6219
Quick View
Haystack MRD Test
Haystack MRD™ is a tumor-informed, liquid biopsy test that begins with tumor whole-exome sequencing (WES) to identify patient-specific somatic mutations. A personalized MRD test is then developed to detect ctDNA, which indicates the presence of residual, recurrent, or resistant disease.

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Haystack MRD
Foundational clinical efficacy
DYNAMIC is the first interventional, random-controlled trial to demonstrate a significant clinical benefit to utilizing MRD testing to guide adjuvant therapy in early-stage solid tumor patients. Powered by a highly optimized version of the technology employed in DYNAMIC, Haystack MRD is rooted in demonstrated clinical care.

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*Tie J, Cohen J, Lahouel K, et al. Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer. N Engl J Med 2022; 386:2261-2272. DOI: 10.1056/NEJMoa2200075
Proven MRD test superiority
This unique ability delivers unmatched sensitivity, with successful detection down to 1 part per million (PPM; or, 0.0001% tumor fraction), which translates to fewer false-negatives to ensure patients who need treatment receive it, and for greater lead time between molecular and clinical recurrence.
Deeper residual disease detection
With an error rate that is >100x lower than other solid tumor MRD tests, the cutoff for MRD detection can be set much lower, dramatically improving sensitivity.
Earlier recurrent disease detection
Better sensitivity means molecular recurrence can be detected at lower levels and with greater lead time in advance of clinical recurrence compared to other methods.
More-confident mutation detection
With an error rate that is 100x lower than other solid tumor MRD tests, Haystack MRD delivers greater confidence in ctDNA test results.
News & Events
The Latest
Find out what's happening at Haystack Oncology and stay up-to-date with industry news.
Quest Diagnostics Completes Acquisition of Haystack Oncology, Adding Sensitive MRD Liquid Biopsy Technology to Cancer Diagnostics Portfolio
SECAUCUS, N.J., June 21, 2023 /PRNewswire/ -- Quest Diagnostics (NYSE:DGX), the nation's leading provider of diagnostic information services, to ...